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In the early twentieth century, neurologist Stern and his team, investigating substance transportation between the brain, cerebrospinal fluid, and peripheral blood, identified a semipermeable barrier separating the brain from the rest of the body, facilitating bidirectional movement, and named it the bloodbrain barrier

It has been found that persistent use of PPIs causes nutritional deficiencies (magnesium, vitamin B12, and iron), kidney damage, osteoporosis, rhabdomyolysis, anemia, thrombocytopenia (Heidelbaugh and Inadomi 2006), and neurological ailments (Ortiz-Guerrero et al

The latter generate, in these glial cells, reactive nitrogenous species including inducible nitric oxide synthase (iNOS) and NADPH oxydase (NOX2)