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IGF-1 Changes in Chronic Conditions and Aging-Associated Sarcopenia Local overexpression of IGF-1 has successfully rescued muscles in various chronic and experimental muscle atrophy models including Dex injected rats [115], age-related muscle atrophy [113], hindlimb suspension [156], and Ang II infusion in rodents [39,74,76], as well as in the mouse models of ALS [157] and muscular dystrophy [158,159,160]

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