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This study is to explore a GSH-responsive AP probe-net, which can be activated by the abundant GSH in ATC cells to generate reactive alkoxyamine, and the formed alkoxyamine can trap AP sites and block the APE1 activity, leading to ATC cell death but less adverse effects towards normal cells

By simultaneously enhancing protein synthesis through mTOR activation and reducing protein degradation through FoxO inhibition, IGF-1 LR3 shifts the net protein balance dramatically toward anabolism

Activation of ferroptosis would be helpful to enhance sensitivity of cancer cells to chemotherapeutic agents (Zheng and Guan, 2023)

Gynecol Obstet Invest 66:5962 Wu MH, Hsiao KY, Tsai SJ (2019) Hypoxia: the force of endometriosis