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Fibrotic Foundation: From Structural Rigidity to Functional Stasis Progressive intestinal fibrosis in SSc is driven by microvascular injury, oxidative stress, and aberrant cytokine signaling mediated by transforming growth factor- (TGF-), connective tissue growth factor (CTGF), and platelet-derived growth factor (PDGF) [13,14,15]

Shao D, Li M, Wang Z, Zheng X, Lao YH, Chang Z, et al

Elevated temperatures accelerate chemical reactions, including hydrolysis and oxidation, which can break peptide bonds or alter their structure, diminishing their efficacy

Reconstituted solutions: After reconstitution epithalon should be stored at appropriate temperatures and concentrations above 100 g/ml to maintain stability