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Using different durations of AOX therapy may add an important confounder that may impact the interpretation of the results

Abnormal iron metabolism is a significant trigger for ferroptosis, with iron-related proteins including transferrin receptor protein 1 (TfR1), ferritin (FTH and FTL), and iron export proteins playing essential roles in iron homeostasis

In some cases, symptoms precede the classical neurological signs by up to several months, suggesting that digestive dysfunction may, in fact, be an early indicator of TD before progressing to other bodily systems

Leveraging external data in the design and analysis of clinical trials in neuro-oncology