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VC enhances the cytotoxic activity of adoptively transferred CD8 T cells, and also co-operates with immune checkpoint therapy (ICT) in many cancer types, proving that a combination of VC and ICT can be curative in models of mismatch repair deficient tumors with high mutational burden

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Nicotinamide supplementation improved motor neuron survival in the mice, suggesting that Akkermansia was beneficial by supplying this neuroprotective metabolite