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Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

Protein band intensities were quantified using ImageJ software (version 1.60)

This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

Non-glutathione disulfide substrates that employ monothiol mechanism (iii) should not be trapped as Grx(SSR) intermediates, which might explain the rather small number of verified non-glutathione disulfide substrates of glutaredoxins to date