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Effect of metformin and lifestyle interventions on mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study

Biochemical abnormalities resulting from accumulation of hydrogen sulfide and its derivative thiosulfate in crucial tissues including liver, brain, and colonic mucosa leading to inhibition of both short-chain acyl-CoA dehydrogenase with consequent elevation of ethylmalonate, C4- and C5-acylcarnitines predominantly in muscle and brain, and cytochrome c oxidase deficiency, blocking mitochondrial respiration and increasing lactic acid [147,148]

Liu W, Zhou W, Zhao P, Wu T, Gu H, Li Y, Zhong C, Bai H, Zhao N, Huang X (2025) PD-Like pathogenesis in Caenorhabditis elegans intestinally infected with Nocardia farcinica and the underlying molecular mechanisms

Other information: Brand name: Celimax