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651 In chronic unpredictable mild stress-induced depression-like behavior, curcumin supplementation promotes neurocyte proliferation and inhibits neuronal apoptosis, while PGC-1 inhibitor SR18292 reverses the beneficial effects of curcumin on depressed rats

Fluorescent imaging was performed using IVIS to quantify residual capsule signal in situ

While these effects are beneficial in specific contexts such as treating growth hormone deficiency in children, muscle wasting conditions, or severe catabolism, they create unwanted consequences when the goal is simply fat reduction