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10.1007/s00467-010-1627-6 Kumar T, Sharma GS, Singh LR: Homocystinuria: Therapeutic approach

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This facilitates transmembrane flow of Na + , K + , and Ca 2+ , inducing cell membrane depolarization and activating downstream signaling cascades (Figure 2) ( 4 2 receptors are widely distributed in the VTA, NAc, and prefrontal cortex, playing a central role in regulating dopamine release and reinforcement learning (Picciotto et al., 1998)