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Although these neurotrophins are thought to have opposing roles, both play a critical part in shaping long-lasting behavioral changes following substance use

This leads to the release and subsequent cytoplasmic translocation of p53, which in turn activates a transcription-independent pro-apoptotic pathway, facilitating the selective clearance of senescent cells (Kong et al., 2025

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This blend is studied for its potential to support cellular repair, tissue recovery, reduced inflammation, and enhanced systemic resilience through angiogenic, cytoprotective, and regenerative pathways