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Calcium overload is a critical step in programmed necrosis of ARPE-19 cells induced by high-concentration H(2)O(2)

The activation of NRF-2 in liver suppresses the synthesis of fatty acids [70], as observed in this study that included experimental feeding with 8-week-old NRF-2 null mice, and wild-type mice fed experimentally, observing the mRNA of sterol regulatory element-binding protein 1-c and fatty acid synthase as highly expressed in NRF-2 null [71], concluding that the protective action is afforded by the increase of AR