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[DOI] [PubMed] [Google Scholar] 11.Joncourt F, Oberlischraummli AE, Stadler M, Buser K, Franscini L, Fey MF, Cerny T

When the locker room becomes the research lab: BPC-157 A provocative look at how evidence-based medicine breaks when access outpaces research

Wrinkles form from loss of collagen and elastin around the thin eyelid skin, and squinting and smiling contribute to crow's feet around the eyes High UV exposure from squinting: Squinting in sunlight concentrates the orbicularis oculi contraction while simultaneously exposing the delicate periocular skin to UV without the protection people typically apply to other facial areas Thin vascular walls: The periocular area's thin skin makes underlying blood vessels more visible the purplish discoloration of dark circles is largely the color of these vessels showing through transparent skin Crow's feet form through a specific mechanism: the orbicularis oculi muscle contracts the overlying skin folds over years of repetition, the collagen fibers in the fold zone degrade and the crease becomes permanent even without muscle contraction

Because her skin fragility became more and more pronounced, she was referred with a suspicion of a classic or dermatosparaxis type of EDS at the age of 13 years