The cosmetic ingredient regulatory frameworks under which GHK-Cu is used in topical preparations have evaluated the compound for the relevant cosmetic-ingredient endpoints, and the compound has substantial regulated cosmetic use
Haghjooy Javanmard S, Ziaei A, Ziaei S, Ziaei E, Mirmohammad-Sadeghi M
Interactions with Benzodiazepines and Other CNS Depressants Inform patients and caregivers that potentially fatal additive effects may occur if hydrocodone bitartrate and acetaminophen tablets are used with benzodiazepines and other CNS depressants, including alcohol (e.g., non-benzodiazepines, sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids), and not to use these concomitantly unless supervised by a healthcare provider (see WARNINGS and PRECAUTIONS, Drug Interactions)
This 46 differential means a 5mg oral dose delivers roughly the same systemic exposure as a 1mg subcutaneous injection