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Given the characteristics of ferroptosis in OA chondrocytes (manifested as iron overload and exacerbated lipid peroxidation), the dual pathways of Cr precisely target these two key driving factors

In addition, when mitochondria are damaged, apoptosis-inducing factor (AIF) is translocated from the mitochondria to the nucleus, where it may mediate chromatin condensation and large-scale DNA fragmentation by binding to DNA (Hong et al., 2004), leading to cell death (See Figure 2)

Mahmudpour, M., Roozbeh, J., Keshavarz, M., Farrokhi, S

Storage and injection are the two things patients ask about most in the first week, and both are more straightforward than the internet suggests