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Moreover, glutamine is an important source of amide nitrogen for nucleotide synthesis, and it contributes to the activation of the mTORC1 pathway which promotes mTORC1-dependant metabolic reprogramming, increasing the proliferation and growth of tumors [36-40]

This provides an additional layer of protection beyond the pure chemistry of reduced reaction rates

It is also why elevated IGF-1 raises theoretical concerns about cancer promotion in individuals with pre-existing malignancy or strong genetic risk.8 Any peptide protocol in an adult over 60 must include a pre-treatment cancer screen and should not be initiated in individuals with active or recent cancer history without oncology input