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In some of such embodiments, a high viscosity formulation or device is a liquid at room temperature and gels at about between room temperature and body temperature (including an individual with a serious fever, e.g., up to about 42 C.)

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Contact your doctor immediately if you experience any of the following rare but serious side effects, including: Severe allergic reaction: Rash, swelling of the face, lips, tongue, or throat, severe dizziness, or trouble breathing Lung problems: Fluid in your lungs, trouble breathing, worsening of asthma Blood clots: Pain, swelling or warmth in the leg, shortness of breath, chest pain Heart attack: Chest pain or tightness, pain that radiates up your shoulder, arm, neck, or jaw Stroke: Sudden problems with vision, speech, or walking, numbness on one side of your body or face Twisting of your ovary: Sudden onset of severe abdominal pain, nausea, vomiting Ectopic pregnancy: Stomach or pelvic pain (especially on one side), neck pain, nausea and vomiting, shoulder pain, rectal pain This is not a complete list of side effects that may occur

10.1038/cr.2014.99 373 WangK