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It is characterized by lingering inflammation of the thyroid tissue and the presence of autoantibodies against thyroglobulin and thyroid peroxidase (28)

Some JAK inhibitors are effective against one isoform, like decernotinib (under phase III) inhibits only JAK3, AC-410 (under phase I) inhibits only JAK2, and filgotinib (under phase III) [80], and INCB-047986 (under Phase I) inhibits only JAK1, are under clinical investigations

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