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Depending on the dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), by several P450 cytochromes [34]

In addition, DNA demethylation of the distinct Bdnf promoters occurred during memory consolidation and neurogenesis in adult hippocampus (see, Figure 2

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This limitation is partly due to the scarcity of site-specific O-GlcNAc antibodies and methodologies that facilitate site-directed mutagenesis to mimic O-GlcNAc-deficient protein states, in contrast to the well-established resources available for phosphorylation-centric studies