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This drug is widely used as an antifibrinolytic agent and has been found to inhibit plasminogenkeratinocyte interaction leading to decrease in activity of tyrosinase, thereby resulting in decreased synthesis of melanin from the melanocytes.[] Human keratinocytes secrete the urokinase-type plasminogen activator, which increases the activity of melanocytes leading to increased synthesis of melanin and the blockade of this effect may be the mechanism behind therapeutic effect of TA for the treatment of melasma.[] Glutathione is an anti-oxidant tri-peptide, which is normally present in humans and has also been tried successfully as a treatment modality for melasma

However, further in vivo trials with larger sample sizes are required to determine the oral antimicrobial capacity of alkaline water (75)

an environmental pollutant)-induced lipid peroxidation and cell necrosis by blocking CYP2E1-mediated CCL 4 metabolic activation and by upregulating Nrf2 downstream genes for NQO-1, HO-1, GCL, GST, and superoxide dismutase (SOD1) (67, 68)