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To develop cardiac insulin resistance, major factors such as hyperglycemia, hyperlipidemia, oxidative stress, inappropriate activation of sympathetic nervous system and the renin-angiotensin II-aldosterone system (RAAS), and dysregulated secretion of adipokines/cytokines are all significant contributors [139]

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3 Mechanisms of sulforaphane-based neuroprotection 3.1 Sulforaphane and oxidative stress regulation Reactive oxygen species (ROS), such as superoxide anions and hydrogen peroxide, are byproducts of cellular metabolism and function within organelles such as mitochondria, endoplasmic reticulum, and peroxisomes (Juan et al., 2021)