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doi: 10.3390/jcm10040562

With respect to the latter, we have previously demonstrated that apigenin or verapamil, which stimulate ABCC1-mediated drug efflux [57], led to the selective oxidative cell death of multidrug resistant cells expressing ABCC1, in the absence of cytotoxic drugs, due to rapid efflux of intracellular glutathione and a rise in ROS levels [56]

Research indicates that the absorption and bioavailability of LC are maximized at "small dose" supplementation, where carrier-mediated transport dominates at low concentrations, maintaining a substantial degree of linearity (Parkhouse and McKenzie 1984)

Gut: Chronic gut issues (if present) approaching resolution for most mild-to-moderate cases