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A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

The role of OS in ALS pathology, whether as a primary cause of disease or a secondary consequence, is now well recognized and many preclinical and clinical studies have consistently demonstrated that the disease is characterized by high levels of OS markers able to induce cellular damage, impaired cell signalling, and finally cell death [25, 86]

Children aged 4 and older may be considered in specific medical situations, while teenagers and adults should follow age-appropriate dosing guidance to ensure safety and efficacy

Studies on therapeutic peptides increased between 1950 and 1990