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Induction of the MAPK cascade is one of the earliest responses when a plant is under any environmental stress, and there is documentary evidence of this signalling pathway, in turn, regulating various phytohormone-signalling networks and other defence-related pathways during stress

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Since then, seven other statins (atorvastatin, fluvastatin, mevastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin) have received Federal Drug Administration approval

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