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Compounded HRT becomes clinically relevant when FDA-approved options are insufficient for a specific patients situation

Treatment of pernicious anaemia or vitamin B12 deficiency typically involves 1mg injections daily or alternate daily for 1 to 2 weeks meaning the dose is five thousand times smaller than the single dose used in cyanide poisoning, and therefore urinary discolouration is not expected to be observed

Peer review Peer review information Nature Reviews Drug Discovery thanks Michael Nauck, Stefan Trapp and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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