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Studies demonstrate that 16 weeks of swimming exercise activates the AMPK/sirtuin 1 (SIRT1) pathway in the liver of high fat diet (HFD)-fed male C57BL/6J mice, upregulates microtubule-associated protein 1 light chain 3 II/I (LC3II/I) and lysosome-associated membrane protein 1 (LAMP1) expression, enhances lipid droplet colocalization with these two proteins, promotes LD degradation via lipophagy, and suppresses abnormal hepatic LD accumulation in HFD-fed mice [14]

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