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First-generation GHRPs such as GHRP-6 were identified through systematic screening of met-enkephalin analogs and demonstrated potent GH release but with significant off-target effects including appetite stimulation, cortisol elevation, and aldosterone release

SSZ mildly induced cell death and lipid peroxidation in A549, H838, H460, and H2122 cells, but it caused a significantly greater percentage of cell death and lipid peroxidation in LDHB KD cells ( Figure 2f, 2g, Supplementary Figure 4k )

Semaglutide: Demonstrated approximately 15% body weight reduction in 68-week trials

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