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Topical application, the most common route of use, has demonstrated excellent safety with minimal adverse effects reported

The S- and RBD-viral sites are notable for affecting transmission and disease severity, and variants have been shown to accumulate mutations at these sites leading to increased S- and RBD affinity with ACE2 [35]

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A multi-strain probiotic formulation containing Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus , and Lactobacillus sporogenes , administered for 14 days reversed PTSD-like behaviors via MGBA restoration in mice (Khan et al., 2025)