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The importance of transcriptome analysis for PASC assessment is underlined by the fact that a transcriptome-wide investigation showed that processes leading to PASC already start during hospitalization for acute COVID-19 and divergent etiologies for different sets of symptoms were identified, depending on the antibody response to SARS-CoV-2 spike protein

Abbreviations: AA: arachidonic acid

Further research demonstrates that MPs activate hypoxia-inducible factor 1-alpha (HIF-1) expression in mouse TM3 Leydig cells and testicular tissue via the extracellular signal-regulated kinase 1/2 (ERK1/2)/MAPK and AKT pathways, down-regulating steroidogenic acute regulatory protein (StAR) expression