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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Maenner M.J., Shaw K.A., Bakian A.V., Bilder D.A., Durkin M.S., Esler A., Furnier S.M., Hallas L., Hall-Lande J., Hudson A., et al

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These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone

Barrett's is a change in the cells that increases the risk of developing oesophageal cancer, compared to having a normal squamous lining