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Current IADVL guidance has shifted first-line systemic therapy from terbinafine to itraconazole, with terbinafine reserved for documented susceptible strains or fluconazole- or itraconazole-intolerant patients

PMID 23462933

2021 May 28;6(1):188

2.2 Cryptococcus Cryptococcosis is a life-threatening invasive fungal infection primarily caused by Cryptococcus neoformans and Cryptococcus gattii , accounting for approximately 152,000 new cases and 110,000 deaths annually, predominantly among immunocompromised individuals such as HIV/AIDS patients and organ transplant recipients (Kwon-Chung et al., 2014)