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Similarly, the concomitant downregulation of Adam19, a metalloproteinase closely associated with inflammation and oxidative stress-induced tissue remodeling 56 , further reinforces the hypothesis that APP treatment actively promotes endogenous antioxidant defenses and improves redox homeostasis rather than provoking nonspecific oxidative damage

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Conversely, NAD + depletion or Sirtuin inhibition has been demonstrated to result in impaired autophagy flux, lipid droplet accumulation, persistent ROS production, and amplified inflammatory responses (Baeken 2024

DOI: org/10.1161/01.RES.79.6.1143 13