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Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3

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[333] found in the brains of Fmr1 -knockout (KO) mice elevated levels of ROS, GSH, markers of protein oxidation and lipid peroxidation in whole brains, and increased production of NADPH oxidase in the prefrontal cortex, cerebellum, and hippocampus