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For example, GABA-synthesizing glutamic acid decarboxylase 65 ( GAD65/GAD1 ) and GABA receptor alpha 2 ( GABRA2 ) showed age-dependent increase in their DNA methylation (Siegmund et al., 2007), whereas GABA receptor alpha 1 ( GABRA1

4 Circadian rhythms regulate post-IS BBB repair via immune system modulation 4.1 Circadian rhythms orchestrate immune cell-mediated BBB repair following IS After stroke, BBB dysfunction involves several inflammatory mechanisms, including increased matrix metalloproteinases (MMP-2/9), excessive ROS production, polarization of microglia toward pro-inflammatory states, and infiltration of peripheral leukocytes (8891)

European Journal of Nutrition, 54 (2), 251263