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Accessed 03 June 2022

Areas often examined include angiogenesis, collagen organisation, and cellular migration

HGF administration promotes the migration and proliferation of cultured SCs and induces the expression of various neurotrophic factors (Ko et al., 2018)

Other signs and symptoms of ALS include: Tripping and falling Difficulty walking Difficulty with normal daily activities Hand weakness or clumsiness (dropping things) Weakness in the legs, feet, or ankles Abnormal fatigue of the arms and/or legs Slurred speech Trouble swallowing Muscle cramps and twitches Uncontrollable periods of laughing, crying or yawning Cognitive and behavioral changes Shortness of breath is a common symptom of ALS due to the effect on the breathing muscles