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Such multifaceted actions position MOTS-c as a compelling molecule of interest for managing obesity and metabolic dysfunction (though currently these effects have been demonstrated in preclinical research models)

Hypoxia tends to maintain the levels of Hypoxia Inducible Factor (HIF-1), which regulates numerous cellular processes, including angiogenesis and proliferation, and as a result, can cause delayed wound healing ( Extracellular matrix The Extracellular matrix is a key environmental component in healing diabetic wounds, as it acts as a dynamic scaffold for cells and facilitates tissue development and regeneration ( Figure 2 )

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Discussion This study reports on BDNF small dipeptide mimetic GSB-106 being able to protect trophic-deprived cells from apoptosis and promote their survival by triggering the TrkB-dependent activation of downstream pro-survival pathways