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In a retrospective study, this model was able to accurately predict whether the overdose would lead to fatal liver damage

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This process triggers intracellular signaling cascades, leading to increased NLRP3 expression, promotion of myocardial fibrosis, and further acceleration of the progression of atrial fibrillation

Dozio E, Ruscica M, Passafaro L, Dogliotti G, Steffani L, Pagani A, Demartini G, Esposti D, Fraschini F, Magni P (2010) The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells