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Co-administration with simvastatin (a CYP3A substrate) resulted in 8% decrease in extent of absorption (AUCinf) and 5% increase in rate of absorption (Cmax) of simvastatin

Because B12 is water-soluble, excess amounts are safely excreted by the body

Three things to never do with a reconstituted blend: never refreeze it, never store it in the refrigerator door (where temperature swings on every door open), and never expose it to direct sunlight

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