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372,373 Moreover, the -face of Cu I -coordinated His ligand interacts with residues in the second coordination shell including nearly invariant Tyr and Glu residues that are energetically linked to Cu I -mediated allosteric inhibition of DNA binding, suggesting a path for allosteric connectivity
Animal models of muscle crush injury and tendon damage have consistently shown faster functional recovery, improved tissue architecture, and reduced scar formation when TB-500 is administered shortly after the injury
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In experimental models, it is studied in connection with cellular regeneration, tissue protection, and stress responses
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