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Unlike many therapeutic peptides, Dihexa can cross the blood-brain barrier and promote BDNF signaling , a key process for: These effects have made Dihexa of great interest in treating neurological diseases, age-related cognitive decline, and more recently, brain fog and fatigue

Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing ( More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported (Mpakali et al., 2020)

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Non-approved peptides including Epitalon, GHK-Cu, BPC-157, and the GH secretagogues lack long-term human safety data from large trials