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CP-25 can improve the ankle pannus formation in AA rats (144), and its possible mechanism is that it inhibits the plasma membrane localization of G protein-coupled receptor kinase 2 (GRK2) in human umbilical vein endothelial cells (HUVECs) and down-regulates the GRK2-induced endothelial C-X-C chemokine receptor type 4 (CXCR4)-ERK1/2 signaling pathway to exert anti-angiogenic effects

Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

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