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Furthermore, current smokers have been shown to have a higher HCC risk (HR = 2.46, 95% CI = 1.773.43) in a dose-dependent manner with the number of cigarettes smoked [104]

They are usually compared based on research focus rather than a strict better-or-worse hierarchy

Over time, that inefficiency can affect your overall metabolic function, and because testosterone production depends on healthy cellular and metabolic processes, this may indirectly influence hormone balance

Their absence results in defects in mitochondrial biogenesis and mitochondrial protein import, ultimately leading to cell death (Kiyama et al., 2022