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Data Availability Statement The data presented in this study are available on request from the corresponding author.

The extracellular redox environment has been suggested to impact on intracellular redox state and cellular metabolism [7,21]

3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (76)

The review combines results from different studies, highlighting how IF can improve health, such as better metabolism, less inflammation, and help with weight control