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These vesicles carry molecules such as miRNAs, mRNAs, and proteins, which participate in multiple aspects of folliculogenesis, including primordial follicle formation, oocyte development and selection, bidirectional granulosa-oocyte communication, steroid hormone regulation, and modulation of cumulus cell density, viability, proliferation, and apoptosis

However, the rate of improvement slowed the largest changes occurred between weeks 4-8, with weeks 8-12 representing diminishing marginal gains

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