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The 2022 American College of Cardiology Expert Consensus Decision Pathway and the 2019 ESC/EAS dyslipidemia guideline support intensifying lipid-lowering therapy in high-risk patients using statins, ezetimibe, PCSK9 inhibitors, bempedoic acid, inclisiran, and other agents depending on risk category and response (Lloyd-Jones et al., 2022

However, modern research has shown that metabolites not only participate in metabolic reactions but are also important regulatory factors in the intracellular environment and intercellular communication [1]

Because the FDA does not regulate supplements the same way it regulates pharmaceuticals, the burden of quality control is on the brand