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Non-use of hormonal treatments in the 3 to 6 months prior to inclusion is often specified (and sometimes non-use of anti-inflammatory drugs in the days before inclusion), explaining why only 3% of the analysed publications adjust results for hormonal or symptomatic treatments (anti-inflammatory, painkillers, etc

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Early recognition and intervention may prevent chronic remodeling and improve long-term outcomes for this growing patient population

The primary difference is that women may be more sensitive to side effects and should be more cautious when titrating to the advanced range