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Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinsons disease models

In some embodiments, the round window membrane mucoadhesive agent is an alkyl-glycoside wherein the alkyl-glycoside comprises a sugar linked to a hydrophobic alkyl (e.g., an alkyl comprising about 6 to about 25 carbon atoms) by an amide linkage, an amine linkage, a carbamate linkage, an ether linkage, a thioether linkage, an ester linkage, a thioester linkage, a glycosidic linkage, a thioglycosidic linkage, and/or a ureide linkage

They do not contain PEGs, carrageenan, artificial flavours or magnesium stearate

Phenformin treatment significantly reduced viral replication, as shown by lower mean oropharyngeal viral titers in the Treated group (1.1 0.9 10 2 , 0.8 1.3 10 2 , 1.5 1.2 10 1 nsp14 copies/ng of RNA on D1, D2, and D3, respectively) compared to those of the Vehicle group