The altered autoregulation of blood flow cannot meet the metabolic demand of tissues in ME/CFS, leading to tissue hypoxia and subsequent ischaemia/reperfusion injury with its associated symptoms and signs ( Endothelial damage Endothelial cells are important regulators of the immune system (308)

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2.9 Assessment of enzymatic activity Enzyme extraction method described by Mukheriee [22] was applied
Molecular hydrogen saline injection is a method that can rapidly supply a large amount of H 2 into the body and allows H 2 for the direct application to the affected area