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Another oral, non-peptide GLP-1 RA (lotiglipron) has also been withdrawn from development as in early phase clinical trials resulted in elevated liver enzymes which could indicate liver toxicity [30]

Epithalon is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG)

Finally, publicly available snRNA-seq data 35 were integrated with our data, showing that signalling-related proteoforms linked to cognitive resilience may localise to inhibitory SST-INs, whereas cytoskeletal proteoforms linked to frailty may be enriched in excitatory IT populations (Figs

It is important to note that most of these effects have been observed in animal studies, and human clinical trials are currently very limited