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As of 2024, there are small studies to suggest that topical or oral formulations of glutathione can help reduce melasma severity

Briefly, the patients diagnosis was confirmed by biopsy, stained for amyloid using Congo red [51] and/or 99mTc-DPD, 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy, and TTR mutation status was verified by PCR-based sequencing [52]